Projects
Since 2013, the OBS has collaborated with a variety of Principal Investigators (PI) from a range of institutions. Each project, a description of its research objectives, its PI and the affiliated institution can be found below.
We encourage prospective PIs to review the topics for each OBS-affiliated project. Doing so will prevent the overlap of applications from different investigators, and foster collaboration between similar projects.
2021
Maternal stress in pregnancy and neurodevelopmental trajectory
There is evidence indicating stress during pregnancy can modify neurodevelopmental outcomes in children. This study aims to determine whether maternal stress is capable of leaving an epigenetic signature in maternal and infant blood, and how this signature relates to neurodevelopmental trajectories in children.
Dr. Stephen Matthews
University of Toronto
2019
The association between perinatal exposures and child neurodevelopment
The perinatal environment influences child development and later life health. Despite this, many exposures remain poorly characterized in their effects on development. This study was created to analyze the effect of acetaminophen use, folic acid supplementation, and fertility treatments on child neurodevelopment.
Dr. Rayjean Hung
Sinai Health
Identification of early biomarkers for spontaneous preterm labour
Dr. Jens Coorssen
McMaster University
Parental cannabis use in the perinatal period and child outcomes: capturing changes with legalization in the Ontario Birth Study
The primary objective of this study is to determine the prevalence of child exposure to cannabis pre and postnatally in the OBS cohort, as well as trends in prevalence and factors associated with use. This study also aims to generate preliminary data on associated of cannabis exposure with child birth and neurodevelopmental outcomes.
Dr. Julia Knight
Sinai Health
Assessing the age of menarche and the risk of preterm birth
Using the OBS’ clinical and lifestyle questionnaire data, this study aims to find a relationship between a participant’s first occurrence of menstruation, and their risk of a preterm delivery.
Dr. John Snelgrove
Sinai Health
2018
Prenatal alcohol exposure (PAE) harmonization using Maelstrom ReACH catalogue
Alcohol is widely used by women of reproductive age in Canada. PAE leads to a continuum of effects known as Fetal Alcohol Spectrum Disorder, a major public health concern in Canada. This is the first Canadian study to look at the correlates of drinking before, during, and after pregnancy to inform FASD prevention strategies.
Dr. Alan Bocking
Sinai Health
Pregnancy in women with seasonal affective disorder – Main
Reviews report that maternal diet in pregnancy plays a crucial role in fetal brain development. By assessing the prevalence of seasonal affective disorder (SAD) and diets of OBS cohort members, to study the risk of mothers with SAD engaging in a high carbohydrate intake diet, which has been proven to be detrimental to child development. This study is a continuation of the 2014 pilot study.
Dr. Robert Levitan
Sinai Health
2017
Lipidomics: A novel tool to define human placental development and function across pregnancy
This study aims to undertake a large scale longitudinal study to assess lipid profiles in circulating placental exosomes isolated from uncomplicated pregnancies. These assessments will be compared to the lipid profiles of exosomes isolated from pregnancies complicated by preeclampsia, intrauterine growth restriction, and gestational diabetes.
Dr. Isabella Canniggia
Sinai Health
The relationship between maternal body weight and pregnancy outcomes
By determining and comparing epigenetic signatures for each OBS subject selected, this study aims to examine the role of epigenetics as a mediator of gene-environment interactions underlying the development of obesity and its associated metabolic outcomes.
Dr. Stephen Matthews
Sinai Health
The relationship between exposure to antenatal corticosteroids and pregnancy outcomes
Dr. Stephen Matthews
Sinai Health
Risk of adverse events in pregnancy in women with moderate to severe cardiac disease
Dr. Rohan D’Souza
Sinai Health
2016
Peripheral leukocytes as targets for preterm birth prevention
Preterm birth is a leading cause of newborn death worldwide, and is associated with significant cognitive and physiological challenges in later life. Using next generation sequencing, this study aims to characterize the transcriptome in whole blood leukocytes of women undergoing spontaneous preterm labor, compared to women who delivered at full term.
Dr. Stephen Lye
Sinai Health
Leukocytes as endogenous biosensors to create novel diagnostics for pregnancy complications in asymptomatic women
Dr. Stephen Lye
Sinai Health
Maternal cytokines in women with preterm birth enrolled in the OBS
Dr. Stephen Lye
Sinai Health
Characterizing the vaginal microbiome and metabolome of pregnant women with and without a history of infection-related preterm delivery
The objective of this study is to characterize the vaginal microbiome and metabolome of pregnant women with a history of infection-related preterm birth compared to those without a history of non-infection related preterm birth.
Dr. Alan Bocking
Sinai Health
2015
Metagenomic characterization of the vaginal microbiome of pregnant women at higher risk of preterm birth
Dr. Alan Bocking
Sinai Health
2014
Stability of telomere length during pregnancy
Dr. Stephen Lye
Sinai Health
2022
Maternal acetaminophen use and cognitive development at 4 years: the Ontario Birth Study
Acetaminophen is used to manage pain and fever during pregnancy. As there are reports of an association between its use and fetal neurodevelopmental dysregulation, this study investigated a potential relationship using data collected by the OBS. Across different points in pregnancies, there was no relationship between maternal acetaminophen use and child cognitive development.
Dr. Rayjean Hung
Sinai Health
2021
The impact of the COVID-19 pandemic on maternal mental health during pregnancy and postpartum
Perinatal mood and anxiety disorders (PMADs) during gestation can affect parent and newborn outcomes. This study compared pre-pandemic and pandemic maternal mental health throughout pregnancy and post-partum. It identified when individuals are most at risk of PMADs to improve screening and optimize treatment opportunities. Using OBS data, this study found increased depression and anxiety scores during compared to before the pandemic, but only in the postpartum period.
Dr. Stephen Matthews
University of Toronto
2018
The Ontario Birth Study: A prospective pregnancy cohort
An analysis of the OBS, its methods, as well as the quality of data and biospecimens available for researchers.
Dr. Laura Anderson
McMaster University
2017
Antenatal gene expression in OBS women who gave birth pre-term
This study sought to identify novel biomarkers for preterm labor. By accessing OBS samples that are taken prior to birth, this study was able to determine specific changes in gene expression signatures that could be used to help identify people at risk of delivering preterm as well as targets for drugs aimed at preterm birth prevention.
Dr. Stephen Lye
Sinai Health
2016
The role of maternal mental health in predicting spontaneous preterm birth
A comparison of self-reported mental health was conducted to compare people who conceive spontaneously with those who use assisted reproduction technology (ART) to become pregnant. Those who used ART had scores showing less depression, perceived stress and anxiety during their second trimester (24-28 weeks) than mothers who spontaneously conceived. However, there was limited evidence of differences occurring between the groups early in pregnancy or after giving birth. The research contributes to the body of knowledge around mental health during pregnancy and highlights where new investigations might be valuable.
Dr. Alan Bocking
Sinai Health
Tobacco, alcohol, and illicit drug use in the Ontario Birth Study
Dr. Kellie Murphy
Sinai Health
Investigation of the effects of in vitro fertilization on the perinatal mental health and birth outcomes of women pregnant through assisted reproductive technologies
This study seeks to compare the pregnancy and postpartum self reported mood and mental health status of women who conceived with assisted reproductive technology (ART) with those of women who conceived spontaneously.
Dr. Kellie Murphy
Sinai Health
2015
Effects of physical activity prior to and during pregnancy on fetal outcome
As spontaneous preterm labour greatly impacts the health of the baby, this study sought to assess light exercise as a preventative measure for mothers. The researchers found that preterm births were associated with higher levels of anti-inflammatory proteins in the bloodstream. Additionally, higher concentrations of these anti-inflammatory cytokines were linked to mothers with less light exercise during their pregnancy. These findings provide the basis for future targeted studies on how exercise affects specific cytokine markers and how accurate these markers are at predicting preterm birth.
Dr. Stephen Lye
Sinai Health
2014
Pregnancy in women with seasonal affective disorder – pilot
The amino acid tryptophan and the immune system are influenced by the changing of the seasons and both have an impact on fetal development. Pregnant women with Seasonal Affective Disorder (SAD) were found to have different seasonal patterns of tryptophan and an immune-response protein, kynurenine, compared to mothers who did not report being affected by SAD. This pilot study has established hypotheses to test in the full study that will investigate ongoing child development in the OBS Kids cohort.
Dr. Robert Levitan
Sinai Health